diff --git a/eng/native/configurecompiler.cmake b/eng/native/configurecompiler.cmake
index 0be4937c7f8d46..e24f5765413330 100644
--- a/eng/native/configurecompiler.cmake
+++ b/eng/native/configurecompiler.cmake
@@ -54,7 +54,19 @@ add_compile_definitions("$<$<CONFIG:CHECKED>:DEBUG;_DEBUG;_DBG;URTBLDENV_FRIENDL
 add_compile_definitions("$<$<OR:$<CONFIG:RELEASE>,$<CONFIG:RELWITHDEBINFO>>:NDEBUG;URTBLDENV_FRIENDLY=Retail>")
 
 if (MSVC)
-  add_linker_flag(/guard:cf)
+
+  define_property(TARGET PROPERTY CLR_CONTROL_FLOW_GUARD INHERITED BRIEF_DOCS "Controls the /guard:cf flag presence" FULL_DOCS "Set this property to ON or OFF to indicate if the /guard:cf compiler and linker flag should be present")
+  define_property(TARGET PROPERTY CLR_EH_CONTINUATION INHERITED BRIEF_DOCS "Controls the /guard:ehcont flag presence" FULL_DOCS "Set this property to ON or OFF to indicate if the /guard:ehcont compiler flag should be present")
+  define_property(TARGET PROPERTY CLR_EH_OPTION INHERITED BRIEF_DOCS "Defines the value of the /EH option" FULL_DOCS "Set this property to one of the valid /EHxx options (/EHa, /EHsc, /EHa-, ...)")
+
+  set_property(GLOBAL PROPERTY CLR_CONTROL_FLOW_GUARD ON)
+
+  # Remove the /EHsc from the CXX flags so that the compile options are the only source of truth for that
+  string(REPLACE "/EHsc" "" CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS}")
+  set_property(GLOBAL PROPERTY CLR_EH_OPTION /EHsc)
+
+  add_compile_options($<$<COMPILE_LANGUAGE:CXX>:$<TARGET_PROPERTY:CLR_EH_OPTION>>)
+  add_link_options($<$<BOOL:$<TARGET_PROPERTY:CLR_CONTROL_FLOW_GUARD>>:/guard:cf>)
 
   # Linker flags
   #
@@ -841,7 +853,7 @@ if (MSVC)
     add_compile_options($<$<COMPILE_LANGUAGE:C,CXX>:/Gz>)
   endif (CLR_CMAKE_HOST_ARCH_I386)
 
-  add_compile_options($<$<AND:$<COMPILE_LANGUAGE:C,CXX>,$<OR:$<CONFIG:Release>,$<CONFIG:Relwithdebinfo>>>:/GL>)
+  set(CMAKE_INTERPROCEDURAL_OPTIMIZATION $<AND:$<COMPILE_LANGUAGE:C,CXX>,$<OR:$<CONFIG:Release>,$<CONFIG:Relwithdebinfo>>>)
 
   if (CLR_CMAKE_HOST_ARCH_AMD64)
     # The generator expression in the following command means that the /homeparams option is added only for debug builds for C and C++ source files
@@ -850,16 +862,15 @@ if (MSVC)
 
   # enable control-flow-guard support for native components for non-Arm64 builds
   # Added using variables instead of add_compile_options to let individual projects override it
-  set(CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} /guard:cf")
-  set(CMAKE_C_FLAGS "${CMAKE_C_FLAGS} /guard:cf")
+  add_compile_options($<$<AND:$<COMPILE_LANGUAGE:C,CXX>,$<BOOL:$<TARGET_PROPERTY:CLR_CONTROL_FLOW_GUARD>>>:/guard:cf>)
 
   # Enable EH-continuation table and CET-compatibility for native components for amd64 builds except for components of the Mono
   # runtime. Added some switches using variables instead of add_compile_options to let individual projects override it.
   if (CLR_CMAKE_HOST_ARCH_AMD64 AND NOT CLR_CMAKE_RUNTIME_MONO)
-    set(CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} /guard:ehcont")
-    set(CMAKE_C_FLAGS "${CMAKE_C_FLAGS} /guard:ehcont")
-    set(CMAKE_ASM_MASM_FLAGS "${CMAKE_ASM_MASM_FLAGS} /guard:ehcont")
-    add_linker_flag(/guard:ehcont)
+    set_property(GLOBAL PROPERTY CLR_EH_CONTINUATION ON)
+
+    add_compile_options($<$<AND:$<COMPILE_LANGUAGE:C,CXX,ASM_MASM>,$<BOOL:$<TARGET_PROPERTY:CLR_EH_CONTINUATION>>>:/guard:ehcont>)
+    add_link_options($<$<BOOL:$<TARGET_PROPERTY:CLR_EH_CONTINUATION>>:/guard:ehcont>)
     set(CMAKE_SHARED_LINKER_FLAGS "${CMAKE_SHARED_LINKER_FLAGS} /CETCOMPAT")
   endif (CLR_CMAKE_HOST_ARCH_AMD64 AND NOT CLR_CMAKE_RUNTIME_MONO)
 
@@ -888,7 +899,9 @@ if (MSVC)
   endif (CLR_CMAKE_TARGET_ARCH_ARM OR CLR_CMAKE_TARGET_ARCH_ARM64)
 
   # Don't display the output header when building RC files.
-  add_compile_options($<$<COMPILE_LANGUAGE:RC>:/nologo>)
+  set(CMAKE_RC_FLAGS "${CMAKE_RC_FLAGS} /nologo")
+  # Don't display the output header when building asm files.
+  set(CMAKE_ASM_MASM_FLAGS "${CMAKE_ASM_MASM_FLAGS} /nologo")
 endif (MSVC)
 
 # Configure non-MSVC compiler flags that apply to all platforms (unix-like or otherwise)
diff --git a/eng/native/ijw/IJW.cmake b/eng/native/ijw/IJW.cmake
index 9ef90525dda8ba..4dd7b0ff2cfa8f 100644
--- a/eng/native/ijw/IJW.cmake
+++ b/eng/native/ijw/IJW.cmake
@@ -2,19 +2,13 @@ if (CLR_CMAKE_HOST_WIN32)
 
   function(remove_ijw_incompatible_options options updatedOptions)
     # IJW isn't compatible with Ehsc, which CMake enables by default
-    if(options MATCHES "/EHsc")
-        string(REPLACE "/EHsc" "" options "${options}")
-    endif()
+    set_property(DIRECTORY PROPERTY CLR_EH_OPTION "")
 
     # IJW isn't compatible with CFG
-    if(options MATCHES "/guard:cf")
-        string(REPLACE "/guard:cf" "" options "${options}")
-    endif()
+    set_property(DIRECTORY PROPERTY CLR_CONTROL_FLOW_GUARD OFF)
 
     # IJW isn't compatible with EHCONT, which requires CFG
-    if(options MATCHES "/guard:ehcont")
-        string(REPLACE "/guard:ehcont" "" options "${options}")
-    endif()
+    set_property(DIRECTORY PROPERTY CLR_EH_CONTINUATION OFF)
 
     # IJW isn't compatible with GR-
     if(options MATCHES "/GR-")
diff --git a/src/coreclr/CMakeLists.txt b/src/coreclr/CMakeLists.txt
index 7946ca99b0df5f..c806c2d3f9aee2 100644
--- a/src/coreclr/CMakeLists.txt
+++ b/src/coreclr/CMakeLists.txt
@@ -73,8 +73,7 @@ endif()
 # Enable C++ EH with SEH
 #-------------------------
 if (MSVC)
-  string(REPLACE "/EHsc" "" CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS}")
-  add_compile_options($<$<COMPILE_LANGUAGE:CXX>:/EHa>) # enable C++ EH (w/ SEH exceptions)
+  set_property(DIRECTORY PROPERTY CLR_EH_OPTION /EHa) # enable C++ EH (w/ SEH exceptions)
 endif()
 
 #-------------------------------
diff --git a/src/coreclr/dlls/clretwrc/CMakeLists.txt b/src/coreclr/dlls/clretwrc/CMakeLists.txt
index 2b749fd7b3736f..2729a6072269bc 100644
--- a/src/coreclr/dlls/clretwrc/CMakeLists.txt
+++ b/src/coreclr/dlls/clretwrc/CMakeLists.txt
@@ -8,9 +8,10 @@ if(CLR_CMAKE_HOST_WIN32)
     string(REPLACE "/LTCG" "" CMAKE_STATIC_LINKER_FLAGS_RELWITHDEBINFO ${CMAKE_STATIC_LINKER_FLAGS_RELWITHDEBINFO})
 
     # remove /guard:cf, /guard:ehcont, and /CETCOMPAT from resource-only libraries
-    string(REPLACE "/guard:cf" "" CMAKE_SHARED_LINKER_FLAGS ${CMAKE_SHARED_LINKER_FLAGS})
+    set_property(DIRECTORY PROPERTY CLR_CONTROL_FLOW_GUARD OFF)
+
     if (CLR_CMAKE_HOST_ARCH_AMD64)
-        string(REPLACE "/guard:ehcont" "" CMAKE_SHARED_LINKER_FLAGS ${CMAKE_SHARED_LINKER_FLAGS})
+        set_property(DIRECTORY PROPERTY CLR_EH_CONTINUATION OFF)
         string(REPLACE "/CETCOMPAT" "" CMAKE_SHARED_LINKER_FLAGS ${CMAKE_SHARED_LINKER_FLAGS})
     endif (CLR_CMAKE_HOST_ARCH_AMD64)
 
diff --git a/src/coreclr/dlls/mscordac/CMakeLists.txt b/src/coreclr/dlls/mscordac/CMakeLists.txt
index 4b1ff24ccdceb9..ea49cb0ad4098a 100644
--- a/src/coreclr/dlls/mscordac/CMakeLists.txt
+++ b/src/coreclr/dlls/mscordac/CMakeLists.txt
@@ -144,7 +144,7 @@ if(CLR_CMAKE_HOST_WIN32)
     add_custom_command(
         DEPENDS mscordaccore_def "${CURRENT_BINARY_DIR_FOR_CONFIG}/mscordac.def" mscordacobj daccess
         OUTPUT ${CMAKE_CURRENT_BINARY_DIR}/mscordaccore.exp
-        COMMAND lib.exe /OUT:"${CMAKE_CURRENT_BINARY_DIR}/mscordaccore.lib" /DEF:"${CURRENT_BINARY_DIR_FOR_CONFIG}/mscordac.def" "$<TARGET_FILE:daccess>" $<$<OR:$<CONFIG:Release>,$<CONFIG:Relwithdebinfo>>:/LTCG> ${STATIC_LIBRARY_FLAGS} $<TARGET_OBJECTS:mscordacobj>
+        COMMAND lib.exe /NOLOGO /OUT:"${CMAKE_CURRENT_BINARY_DIR}/mscordaccore.lib" /DEF:"${CURRENT_BINARY_DIR_FOR_CONFIG}/mscordac.def" "$<TARGET_FILE:daccess>" $<$<OR:$<CONFIG:Release>,$<CONFIG:Relwithdebinfo>>:/LTCG> ${STATIC_LIBRARY_FLAGS} $<TARGET_OBJECTS:mscordacobj>
         COMMENT "Generating mscordaccore.exp export file"
     )
 
diff --git a/src/coreclr/dlls/mscorrc/CMakeLists.txt b/src/coreclr/dlls/mscorrc/CMakeLists.txt
index 8011997c1e55fc..30b2bf1eda69da 100644
--- a/src/coreclr/dlls/mscorrc/CMakeLists.txt
+++ b/src/coreclr/dlls/mscorrc/CMakeLists.txt
@@ -9,9 +9,10 @@ if(CLR_CMAKE_HOST_WIN32)
     string(REPLACE "/LTCG" "" CMAKE_SHARED_LINKER_FLAGS_RELWITHDEBINFO ${CMAKE_SHARED_LINKER_FLAGS_RELWITHDEBINFO})
 
     # remove /guard:cf, /guard:ehcont, and /CETCOMPAT from resource-only libraries
-    string(REPLACE "/guard:cf" "" CMAKE_SHARED_LINKER_FLAGS ${CMAKE_SHARED_LINKER_FLAGS})
+    set_property(DIRECTORY PROPERTY CLR_CONTROL_FLOW_GUARD OFF)
+
     if (CLR_CMAKE_HOST_ARCH_AMD64)
-        string(REPLACE "/guard:ehcont" "" CMAKE_SHARED_LINKER_FLAGS ${CMAKE_SHARED_LINKER_FLAGS})
+        set_property(DIRECTORY PROPERTY CLR_EH_CONTINUATION OFF)
         string(REPLACE "/CETCOMPAT" "" CMAKE_SHARED_LINKER_FLAGS ${CMAKE_SHARED_LINKER_FLAGS})
     endif (CLR_CMAKE_HOST_ARCH_AMD64)
 
diff --git a/src/coreclr/inc/CMakeLists.txt b/src/coreclr/inc/CMakeLists.txt
index 0733379b024093..cae1e5c07b7565 100644
--- a/src/coreclr/inc/CMakeLists.txt
+++ b/src/coreclr/inc/CMakeLists.txt
@@ -27,7 +27,7 @@ if(CLR_CMAKE_HOST_WIN32)
         set(OUT_NAME ${CMAKE_CURRENT_BINARY_DIR}/idls_out/${IDLNAME}_i.c)
         list(APPEND CORGUIDS_SOURCES ${OUT_NAME})
         add_custom_command(OUTPUT ${OUT_NAME}
-                      COMMAND ${MIDL} ${MIDL_INCLUDE_DIRECTORIES} /no_stamp /h ${CMAKE_CURRENT_BINARY_DIR}/idls_out/${IDLNAME}.h ${MIDL_DEFINITIONS} /out ${CMAKE_CURRENT_BINARY_DIR}/idls_out ${CMAKE_CURRENT_SOURCE_DIR}/${GENERATE_IDL}
+                      COMMAND ${MIDL} ${MIDL_INCLUDE_DIRECTORIES} /nologo /no_stamp /h ${CMAKE_CURRENT_BINARY_DIR}/idls_out/${IDLNAME}.h ${MIDL_DEFINITIONS} /out ${CMAKE_CURRENT_BINARY_DIR}/idls_out ${CMAKE_CURRENT_SOURCE_DIR}/${GENERATE_IDL}
                       DEPENDS ${CMAKE_CURRENT_SOURCE_DIR}/${GENERATE_IDL}
                       COMMENT "Compiling ${GENERATE_IDL}")
     endforeach(GENERATE_IDL)
diff --git a/src/coreclr/nativeaot/Bootstrap/base/CMakeLists.txt b/src/coreclr/nativeaot/Bootstrap/base/CMakeLists.txt
index 3ffc81ac648b09..22c194d7fafb74 100644
--- a/src/coreclr/nativeaot/Bootstrap/base/CMakeLists.txt
+++ b/src/coreclr/nativeaot/Bootstrap/base/CMakeLists.txt
@@ -12,7 +12,7 @@ install_bootstrapper_object(bootstrapper aotsdk)
 if (CLR_CMAKE_TARGET_WIN32)
   add_library(bootstrapper.GuardCF OBJECT ${SOURCES})
   install_bootstrapper_object(bootstrapper.GuardCF aotsdk)
-  target_compile_options(bootstrapper.GuardCF PRIVATE $<$<OR:$<COMPILE_LANGUAGE:C>,$<COMPILE_LANGUAGE:CXX>>:/guard:cf>)
+  set_target_properties(bootstrapper.GuardCF PROPERTIES CLR_CONTROL_FLOW_GUARD ON)
 else()
   add_library(stdc++compat STATIC ../stdcppshim.cpp)
   install_static_library(stdc++compat aotsdk nativeaot)
diff --git a/src/coreclr/nativeaot/Bootstrap/dll/CMakeLists.txt b/src/coreclr/nativeaot/Bootstrap/dll/CMakeLists.txt
index 14eb3ece8e1e04..263518e4b006f3 100644
--- a/src/coreclr/nativeaot/Bootstrap/dll/CMakeLists.txt
+++ b/src/coreclr/nativeaot/Bootstrap/dll/CMakeLists.txt
@@ -13,5 +13,5 @@ install_bootstrapper_object(bootstrapperdll aotsdk)
 if (CLR_CMAKE_TARGET_WIN32)
   add_library(bootstrapperdll.GuardCF STATIC ${SOURCES})
   install_bootstrapper_object(bootstrapperdll.GuardCF aotsdk)
-  target_compile_options(bootstrapperdll.GuardCF PRIVATE $<$<OR:$<COMPILE_LANGUAGE:C>,$<COMPILE_LANGUAGE:CXX>>:/guard:cf>)
+  set_target_properties(bootstrapperdll.GuardCF PROPERTIES CLR_CONTROL_FLOW_GUARD ON)
 endif()
diff --git a/src/coreclr/nativeaot/CMakeLists.txt b/src/coreclr/nativeaot/CMakeLists.txt
index 74bf4449e24c7c..557a70ed48db97 100644
--- a/src/coreclr/nativeaot/CMakeLists.txt
+++ b/src/coreclr/nativeaot/CMakeLists.txt
@@ -3,20 +3,11 @@ if(WIN32)
 endif (WIN32)
 
 if(MSVC)
-  add_compile_options($<$<COMPILE_LANGUAGE:CXX>:/EHa->)   # Native AOT runtime does not use C++ exception handling
-  add_compile_options($<$<COMPILE_LANGUAGE:CXX>:/EHs->)
-
-  # CFG runtime checks in C++ code are unnecessary overhead unless Native AOT compiler produces CFG compliant code as well
-  # and CFG is enabled in the linker
-  if(CMAKE_CXX_FLAGS MATCHES "/guard:cf")
-    string(REPLACE "/guard:cf" "" CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS}")
-  endif()
-  if(CMAKE_C_FLAGS MATCHES "/guard:cf")
-    string(REPLACE "/guard:cf" "" CMAKE_C_FLAGS "${CMAKE_C_FLAGS}")
-  endif()
+  set_property(DIRECTORY PROPERTY CLR_EH_OPTION /EHa-s-)   # Native AOT runtime does not use C++ exception handling
+  set_property(DIRECTORY PROPERTY CLR_CONTROL_FLOW_GUARD OFF)
 
   # The code generated by the Native AOT compiler doesn't work with Link Time Code Generation
-  add_compile_options($<$<COMPILE_LANGUAGE:C,CXX>:/GL->)
+  set(CMAKE_INTERPROCEDURAL_OPTIMIZATION OFF)
 
   # Sets the options that create the fastest code in the majority of cases
   add_compile_options($<$<AND:$<COMPILE_LANGUAGE:C,CXX>,$<CONFIG:Release>>:/O2>)
diff --git a/src/coreclr/nativeaot/Runtime/Full/CMakeLists.txt b/src/coreclr/nativeaot/Runtime/Full/CMakeLists.txt
index 3cbaa6e2f253a6..2d2858dfaedfdc 100644
--- a/src/coreclr/nativeaot/Runtime/Full/CMakeLists.txt
+++ b/src/coreclr/nativeaot/Runtime/Full/CMakeLists.txt
@@ -40,11 +40,11 @@ target_compile_definitions(Runtime.ServerGC PRIVATE -DFEATURE_SVR_GC)
 if (CLR_CMAKE_TARGET_WIN32)
   add_library(Runtime.ServerGC.GuardCF STATIC ${COMMON_RUNTIME_SOURCES} ${FULL_RUNTIME_SOURCES} ${RUNTIME_SOURCES_ARCH_ASM} ${SERVER_GC_SOURCES} ${RUNTIME_ARCH_ASM_OBJECTS})
   target_compile_definitions(Runtime.ServerGC.GuardCF PRIVATE -DFEATURE_SVR_GC)
-  target_compile_options(Runtime.ServerGC.GuardCF PRIVATE $<$<OR:$<COMPILE_LANGUAGE:C>,$<COMPILE_LANGUAGE:CXX>>:/guard:cf>)
+  set_target_properties(Runtime.ServerGC.GuardCF PROPERTIES CLR_CONTROL_FLOW_GUARD ON)
 
   if (CLR_CMAKE_TARGET_ARCH_AMD64)
     add_library(Runtime.VxsortEnabled.GuardCF STATIC ${VXSORT_SOURCES})
-    target_compile_options(Runtime.VxsortEnabled.GuardCF PRIVATE $<$<OR:$<COMPILE_LANGUAGE:C>,$<COMPILE_LANGUAGE:CXX>>:/guard:cf>)
+    set_target_properties(Runtime.VxsortEnabled.GuardCF PROPERTIES CLR_CONTROL_FLOW_GUARD ON)
   endif (CLR_CMAKE_TARGET_ARCH_AMD64)
 endif (CLR_CMAKE_TARGET_WIN32)
 
@@ -55,7 +55,7 @@ set(ASM_OFFSETS_CSPP ${RUNTIME_DIR}/../Runtime.Base/src/AsmOffsets.cspp)
 
 if(WIN32)
     set(COMPILER_LANGUAGE "")
-    set(PREPROCESSOR_FLAGS -EP)
+    set(PREPROCESSOR_FLAGS -EP -nologo)
     set(ASM_OFFSETS_CPP ${RUNTIME_DIR}/windows/AsmOffsets.cpp)
 else()
     set(COMPILER_LANGUAGE -x c++)
diff --git a/src/coreclr/nativeaot/Runtime/Portable/CMakeLists.txt b/src/coreclr/nativeaot/Runtime/Portable/CMakeLists.txt
index ea7b5a348eb233..5d19a4eb9eda04 100644
--- a/src/coreclr/nativeaot/Runtime/Portable/CMakeLists.txt
+++ b/src/coreclr/nativeaot/Runtime/Portable/CMakeLists.txt
@@ -13,7 +13,7 @@ set(ASM_OFFSETS_CSPP ${RUNTIME_DIR}/../Runtime.Base/src/AsmOffsets.cspp)
 
 if(WIN32)
     set(COMPILER_LANGUAGE "")
-    set(PREPROCESSOR_FLAGS -EP)
+    set(PREPROCESSOR_FLAGS -EP -nologo)
     set(ASM_OFFSETS_CPP ${RUNTIME_DIR}/windows/AsmOffsets.cpp)
 else()
     set(COMPILER_LANGUAGE -x c++)
diff --git a/src/coreclr/nativeaot/Runtime/eventpipe/CMakeLists.txt b/src/coreclr/nativeaot/Runtime/eventpipe/CMakeLists.txt
index 27f07197287994..3dd73aaaaf75b7 100644
--- a/src/coreclr/nativeaot/Runtime/eventpipe/CMakeLists.txt
+++ b/src/coreclr/nativeaot/Runtime/eventpipe/CMakeLists.txt
@@ -160,8 +160,8 @@ add_library(eventpipe-disabled STATIC ${AOT_EVENTPIPE_DISABLED_SOURCES})
 if (CLR_CMAKE_TARGET_WIN32)
   add_library(eventpipe-enabled.GuardCF STATIC ${EVENTPIPE_SOURCES})
   add_library(eventpipe-disabled.GuardCF STATIC ${AOT_EVENTPIPE_DISABLED_SOURCES})
-  target_compile_options(eventpipe-enabled.GuardCF PRIVATE $<$<OR:$<COMPILE_LANGUAGE:C>,$<COMPILE_LANGUAGE:CXX>>:/guard:cf>)
-  target_compile_options(eventpipe-disabled.GuardCF PRIVATE $<$<OR:$<COMPILE_LANGUAGE:C>,$<COMPILE_LANGUAGE:CXX>>:/guard:cf>)
+  set_target_properties(eventpipe-enabled.GuardCF PROPERTIES CLR_CONTROL_FLOW_GUARD ON)
+  set_target_properties(eventpipe-disabled.GuardCF PROPERTIES CLR_CONTROL_FLOW_GUARD ON)
 endif (CLR_CMAKE_TARGET_WIN32)
 
 install_static_library(eventpipe-enabled aotsdk nativeaot)
diff --git a/src/native/corehost/CMakeLists.txt b/src/native/corehost/CMakeLists.txt
index 249e4d52cf2647..0f35d2cdb2f667 100644
--- a/src/native/corehost/CMakeLists.txt
+++ b/src/native/corehost/CMakeLists.txt
@@ -8,7 +8,7 @@ include(${CLR_ENG_NATIVE_DIR}/configurecompiler.cmake)
 
 if (MSVC)
     # Host components don't try to handle asynchronous exceptions
-    add_compile_options($<$<COMPILE_LANGUAGE:CXX>:/EHsc>)
+    set_property(DIRECTORY PROPERTY CLR_EH_OPTION /EHsc)
 
     # Explicitly re-enable warnings about declaration hiding (currently disabled by configurecompiler.cmake)
     add_compile_options($<$<COMPILE_LANGUAGE:C,CXX>:/we4456>) # declaration of 'identifier' hides previous local declaration
diff --git a/src/native/corehost/apphost/static/CMakeLists.txt b/src/native/corehost/apphost/static/CMakeLists.txt
index e1a02ece410912..0bced59e7f10b9 100644
--- a/src/native/corehost/apphost/static/CMakeLists.txt
+++ b/src/native/corehost/apphost/static/CMakeLists.txt
@@ -46,7 +46,7 @@ include(../../hostcommon/files.cmake)
 
 if(MSVC)
     # Host components don't try to handle asynchronous exceptions
-    add_compile_options(/EHsc)
+    set_property(DIRECTORY PROPERTY CLR_EH_OPTION /EHsc)
 elseif (CMAKE_CXX_COMPILER_ID MATCHES GNU)
     # Prevents libc from calling pthread_cond_destroy on static objects in
     # dlopen()'ed library which we dlclose() in pal::unload_library.
diff --git a/src/native/corehost/fxr/staticlib/CMakeLists.txt b/src/native/corehost/fxr/staticlib/CMakeLists.txt
index 284d751f7c9079..6ff3bc27f74c19 100644
--- a/src/native/corehost/fxr/staticlib/CMakeLists.txt
+++ b/src/native/corehost/fxr/staticlib/CMakeLists.txt
@@ -32,7 +32,7 @@ if (MSVC)
     # We ship libhostfxr.lib as a static library for external consumption, so
     # LTCG must be disabled to ensure that non-MSVC toolchains can work with it.
 
-    target_compile_options(libhostfxr PRIVATE /GL-)
+    set_target_properties(libhostfxr PROPERTIES INTERPROCEDURAL_OPTIMIZATION OFF)
 
     string(REPLACE "/LTCG" "" CMAKE_STATIC_LINKER_FLAGS_RELEASE ${CMAKE_STATIC_LINKER_FLAGS_RELEASE})
     string(REPLACE "/LTCG" "" CMAKE_STATIC_LINKER_FLAGS_RELWITHDEBINFO ${CMAKE_STATIC_LINKER_FLAGS_RELWITHDEBINFO})
diff --git a/src/native/corehost/nethost/CMakeLists.txt b/src/native/corehost/nethost/CMakeLists.txt
index 5ae3f76e8fe4db..818ed9ced7fce6 100644
--- a/src/native/corehost/nethost/CMakeLists.txt
+++ b/src/native/corehost/nethost/CMakeLists.txt
@@ -42,7 +42,7 @@ if (MSVC)
     # We ship libnethost.lib as a static library for external consumption, so
     # LTCG must be disabled to ensure that non-MSVC toolchains can work with it.
 
-    target_compile_options(libnethost PRIVATE /GL-)
+    set_target_properties(libnethost PROPERTIES INTERPROCEDURAL_OPTIMIZATION OFF)
 
     string(REPLACE "/LTCG" "" CMAKE_STATIC_LINKER_FLAGS_RELEASE ${CMAKE_STATIC_LINKER_FLAGS_RELEASE})
     string(REPLACE "/LTCG" "" CMAKE_STATIC_LINKER_FLAGS_RELWITHDEBINFO ${CMAKE_STATIC_LINKER_FLAGS_RELWITHDEBINFO})
diff --git a/src/native/corehost/test/typelibs/CMakeLists.txt b/src/native/corehost/test/typelibs/CMakeLists.txt
index 0b21548ef96fd2..ca39ef86f0a800 100644
--- a/src/native/corehost/test/typelibs/CMakeLists.txt
+++ b/src/native/corehost/test/typelibs/CMakeLists.txt
@@ -17,6 +17,7 @@ function(compile_idl idl_file tlb_out)
             /h ${CMAKE_CURRENT_BINARY_DIR}/${IDL_NAME}.h ${MIDL_DEFINITIONS}
             /out ${CMAKE_CURRENT_BINARY_DIR}
             /tlb ${tlb_out_local}
+            /nologo
             ${IDL_SOURCE}
         DEPENDS ${IDL_SOURCE}
         COMMENT "Compiling ${IDL_SOURCE}")
diff --git a/src/native/external/libunwind_extras/CMakeLists.txt b/src/native/external/libunwind_extras/CMakeLists.txt
index 245bd3823169e5..86db33a4fedd09 100644
--- a/src/native/external/libunwind_extras/CMakeLists.txt
+++ b/src/native/external/libunwind_extras/CMakeLists.txt
@@ -123,7 +123,6 @@ if(CLR_CMAKE_HOST_WIN32)
     endif ()
 
     # Assume we are using default MSVC compiler
-    add_compile_options(/TC) # compile all files as C
     add_compile_options(/permissive-)
 
     # include paths
@@ -162,6 +161,10 @@ endif()
 include(configure.cmake)
 include(${CLR_SRC_NATIVE_DIR}/external/libunwind.cmake)
 
+if(CLR_CMAKE_HOST_WIN32)
+    set_source_files_properties(${LIBUNWIND_SOURCES} PROPERTIES COMPILE_FLAGS /TC) # compile all files as C
+endif(CLR_CMAKE_HOST_WIN32)
+
 if(CLR_CMAKE_HOST_UNIX)
     if(CLR_CMAKE_HOST_OSX)
         add_library(libunwind_dac OBJECT ${LIBUNWIND_SOURCES})
diff --git a/src/native/libs/System.Globalization.Native/CMakeLists.txt b/src/native/libs/System.Globalization.Native/CMakeLists.txt
index d6dfcb65bf3284..aac9b46c61c5dd 100644
--- a/src/native/libs/System.Globalization.Native/CMakeLists.txt
+++ b/src/native/libs/System.Globalization.Native/CMakeLists.txt
@@ -165,8 +165,8 @@ if(CLR_CMAKE_TARGET_WIN32)
             STATIC
             ${NATIVEGLOBALIZATION_SOURCES}
         )
-        target_compile_options(System.Globalization.Native.Aot PRIVATE /guard:cf-)
-        target_compile_options(System.Globalization.Native.Aot PRIVATE /GL-)
+        set_target_properties(System.Globalization.Native.Aot PROPERTIES CLR_CONTROL_FLOW_GUARD OFF)
+        set_target_properties(System.Globalization.Native.Aot PROPERTIES INTERPROCEDURAL_OPTIMIZATION OFF)
 
         add_library(System.Globalization.Native.Aot.GuardCF
             STATIC
diff --git a/src/native/libs/System.IO.Compression.Native/CMakeLists.txt b/src/native/libs/System.IO.Compression.Native/CMakeLists.txt
index b8a726542ce3ad..0b1cdea3a594e2 100644
--- a/src/native/libs/System.IO.Compression.Native/CMakeLists.txt
+++ b/src/native/libs/System.IO.Compression.Native/CMakeLists.txt
@@ -136,8 +136,8 @@ else ()
             STATIC
             ${NATIVECOMPRESSION_SOURCES}
         )
-        target_compile_options(System.IO.Compression.Native.Aot PRIVATE /guard:cf-)
-        target_compile_options(System.IO.Compression.Native.Aot PRIVATE /GL-)
+        set_target_properties(System.IO.Compression.Native.Aot PROPERTIES CLR_CONTROL_FLOW_GUARD OFF)
+        set_target_properties(System.IO.Compression.Native.Aot PROPERTIES INTERPROCEDURAL_OPTIMIZATION OFF)
 
         add_library(System.IO.Compression.Native.Aot.GuardCF
             STATIC
diff --git a/src/tests/CMakeLists.txt b/src/tests/CMakeLists.txt
index 6167f236a25baf..bb18388c940a0a 100644
--- a/src/tests/CMakeLists.txt
+++ b/src/tests/CMakeLists.txt
@@ -38,8 +38,7 @@ if (CLR_CMAKE_HOST_WIN32)
     # 5039 - pointer or reference to potentially throwing function passed to extern C function under -EHc. Undefined behavior may occur if this function throws an exception.
     add_compile_options(-wd4100 -wd4244 -wd4514 -wd4625 -wd4626 -wd4668 -wd4710 -wd4711 -wd4774 -wd4820 -wd5025 -wd5026 -wd5027 -wd5039)
 
-    string(REPLACE "/EHsc" "" CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS}")
-    add_compile_options(/EHa) # enable C++ EH (w/ SEH exceptions)
+    set_property(DIRECTORY PROPERTY CLR_EH_OPTION /EHa) # enable C++ EH (w/ SEH exceptions)
 endif()
 
 MACRO(SUBDIRLIST result curdir)